Rectal Cancer and Diabetes Relationship: An Evidence-Based Overview for Healthcare Providers

Abstract As the third most frequently diagnosed cancer through worldwide, colorectal (CRC) is fourth leading cause and account for around 8% of all cancer-related death. Diabetes mellitus (DM) a complex metabolic disorder characterized by chronic hyperglycemia inflammation due to deficiency in insulin secretion or dysregulation action pathway, which further leads dysfunction failure multiple organs. Many advances have been made diagnosis management rectal cancer. Although survival severely dependent on stage disease at diagnosis, it might also be influenced several risk factors. The relationship between diabetes one can raise problems both patients with conditions. Metabolic pathways type II diabetes, glucose intolerance obesity considered as link This article provides not just an overview epidemiology, CRC DM, but highlights DM relationship.